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Overall, Nrf2 is fundamental for the sustenance of the GSH redox state through glutathione reductase transcriptional regulation and for cell protection against oxidative stress (Harvey et al., 2009)

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The selection phase was divided into two distinct stages: the initial screening with the reading of titles and abstracts and the final selection with the identification of rat experiments that used melatonin and assessed the effects of its antioxidant actions in situations of high oxidative stress against a control group

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